6533b824fe1ef96bd1280ccb

RESEARCH PRODUCT

Antithrombotic therapy of Cerebral cavernous malformations

Ralf A. KockroBui Bao Khanh DinhGreta GasciauskaiteIsabel WankeJonas GruschwitzChristian Valentin Eisenring

subject

medicine.medical_specialtylcsh:SurgeryCerebral cavernous malformationslcsh:RC346-429Vascular anomalyLesionStereotactic radiotherapySurgical removalAntithromboticmedicinelcsh:Neurology. Diseases of the nervous systemAntithrombotic therapybusiness.industryCerebral cavernous malformationsTreatment of peripheral venous anomaliesAntithrombotic therapy ; Cerebral cavernous malformations ; Slow-flow vascular anomaly ; Intracerebral venous anomaly ; Treatment of peripheral venous anomalieslcsh:RD1-811Cavernous malformationsmedicine.diseaseIntracerebral venous anomalySlow-flow vascular anomalyCavernous sinusSurgeryNeurology (clinical)Radiologymedicine.symptombusiness

description

Abstract Cavernous malformations are recognized as the most common vascular anomalies in the brain, that often lead to hemorrhage with neurological symptoms. Usually the treatment is surgical removal or stereotactic radiotherapy. We present a case of a slow-flow vascular anomaly located in the cavernous sinus with recurrent partial thrombotic areas. Inspired by treatment of peripheral venous anomalies antithrombotic therapy was initiated instead of surgery or stereotactic radiotherapy. This led to complete spontaneous resolution of the lesion and normalization of symptoms within nine months. The patient never showed any symptoms over a period of eight years while continuing antithrombotic therapy. Based on this case this therapy may be a reasonable approach to treat intracerebral venous anomalies.

yearjournalcountryeditionlanguage
2020-12-01Interdisciplinary Neurosurgery
https://doi.org/10.1016/j.inat.2020.100851