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RESEARCH PRODUCT
Double-Network-Structured Graphene Oxide-Containing Nanogels as Photothermal Agents for the Treatment of Colorectal Cancer.
Cinzia ScialabbaFabio Salvatore PalumboGaetano GiammonaNicolò MauroGiovanna PitarresiCalogero Fioricasubject
Models MolecularPolymers and PlasticsColorectal cancerInfrared RaysProtein ConformationNanogelsBioengineeringNanotechnologyAntineoplastic Agents02 engineering and technology010402 general chemistry01 natural scienceslaw.inventionPolyethylene GlycolsBiomaterialschemistry.chemical_compoundgraphene oxide hydrogel nenogel cancer therapylawHyaluronic acidMaterials ChemistrymedicineCytotoxic T cellHumansPolyethyleneimineHyaluronic AcidGrapheneChemistryOxidesPhotothermal therapy021001 nanoscience & nanotechnologymedicine.diseaseHCT116 CellsIn vitro0104 chemical sciencesIrinotecanPhotochemotherapyCancer cellCancer researchGraphite0210 nano-technologyColorectal Neoplasmsmedicine.drugdescription
Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the huge aromatic surface area, allows to easily load high amount of irinotecan (33.0% w/w) and confers to the system hyperthermic properties when irradiated with a near-infrared (NIR) laser beam. We demonstrate that the release of antitumor drug is influenced both by the pH of the external medium and the NIR irradiation process. In vitro biological studies, conducted on human colon cancer cells (HCT 116), revealed that nanogels are uptaken by the cancer cells and, in the presence of the antitumor drug, can produce a synergistic hyperthermic/cytotoxic effect. Finally, 3D experiments demonstrate that it is possible to conduct thermal ablation of solid tumors after the intratumoral administration of nanogels.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-02-20 | Biomacromolecules |