6533b824fe1ef96bd1280d0a

RESEARCH PRODUCT

Childhood methylphenidate treatment of ADHD and response to affective stimuli

Ulrike LehmkuhlJana WraseMeline StoyMichael HussEva FriedelAndreas HeinzLorna H. SchlochtermeierFlorian SchlagenhaufAndreas StröhleSoyoung Q. Park

subject

AdultMalemedicine.medical_specialtyEmotionsDysfunctional familyEmotional processingGyrus CinguliBasal Gangliamental disordersmedicineHumansPharmacology (medical)ChildPsychiatryProspective cohort studyBiological PsychiatryPsychiatric Status Rating ScalesPharmacologyNeural correlates of consciousnessMethylphenidateVentral striatumEmotional dysregulationMagnetic Resonance ImagingPsychiatry and Mental healthmedicine.anatomical_structureNeurologyAttention Deficit Disorder with HyperactivityMethylphenidateNeurology (clinical)PsychologyAffective stimuliClinical psychologymedicine.drug

description

Neural correlates of emotional dysregulation in attention-deficit/hyperactivity disorder (ADHD) and persisting influence of Methylphenidate (MPH) still remain insufficiently understood. Decreased activation in the subgenual cingulate and the ventral striatum were found during the perception of positive and negative affective pictures in drug-naïve males with ADHD during childhood (n=10). Males with ADHD during childhood treated with MPH (n=10) did not show any significant differences compared to healthy controls (n=10). Further prospective studies need to clarify direct and indirect mechanisms of MPH treatment that may contribute to emotional processing, which is dysfunctional in males without pharmacological treatment in childhood.

yearjournalcountryeditionlanguage
2009-11-13European Neuropsychopharmacology
https://doi.org/10.1016/j.euroneuro.2010.05.001