6533b824fe1ef96bd12813eb
RESEARCH PRODUCT
Continuous flow synthesis of amine oxides by oxidation of tertiary amines
Piotr WieczorekThorsten RöderStefan ZikeliPaul AignerTobias BaumeisterHannes Kitzlersubject
Fluid Flow and Transfer Processes010405 organic chemistryChemistryProcess Chemistry and TechnologyBicarbonateActivation energy010402 general chemistry01 natural sciencesCatalysis0104 chemical sciencesCatalysischemistry.chemical_compoundChemical engineeringChemistry (miscellaneous)Carbon dioxideChemical Engineering (miscellaneous)Amine gas treatingChemical equilibriumMicroreactorHydrogen peroxidedescription
The synthesis of N-methylmorpholine N-oxide by oxidation of N-methylmorpholine with hydrogen peroxide was implemented in a microstructured reactor for increased safety and larger-scale applications. The active oxidant, peroxymonocarbonate HCO4− is formed in situ from the equilibrium reaction of hydrogen peroxide and bicarbonate. The bicarbonate can be induced by hydration of carbon dioxide. Elaborate studies on the influence of the catalyst concentration and temperature were carried out and the observed activation energy was determined. Elevated temperatures up to 60 °C and a carbon dioxide concentrations of 1 wt% led to a conversion for N-methylmorpholine of approximately 98% within 13.90 min. The used microstructured reactor is designed for process development and intensification and can be applied in the scale-up process to small-scale commercial production. The atom-economic synthesis of N-methylmorpholine N-oxide under flow conditions in such reactors is a safe and beneficial alternative to commercial batch processes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 | Reaction Chemistry & Engineering |