6533b824fe1ef96bd12814bc
RESEARCH PRODUCT
Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation
La Barbera LidiaMacaluso FedericaFasano SerenaGrasso GiuliaCiccia FrancescoGuggino Giulianasubject
InflammationVasculitisdysbiosiMicrobiotaOrganic ChemistrymicrobiomeGeneral MedicineCatalysisComputer Science ApplicationsInorganic Chemistrychronic immune-mediated inflammatory diseasemicrobiome.DysbiosisHumansPhysical and Theoretical ChemistryConnective Tissue DiseasesMolecular BiologySpectroscopyConnective Tissue DiseaseHumandescription
The microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, known as dysbiosis, might perturb the delicate balance between the microbiota and the immune system, triggering inflammation and potentially contributing to the pathogenesis and development of chronic inflammatory diseases. This review will summarize the current evidence about the microbiome-immunity cross-talk, especially focusing on the microbiota alterations described in patients with rheumatic diseases and on the recent findings concerning the interaction between microbiota, metabolic function, and the immune system.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-06-10 |