6533b824fe1ef96bd128154b

RESEARCH PRODUCT

Metal complexes of phenobarbituric acid. Chelating behavior of the phenobarbiturate ring. Anticonvulsant properties of the K2[Cu(N-methylphenobarbiturato)]4.8H2O.

Joaquín BorrásI. SevillaL. Perelló

subject

Magnetic Resonance SpectroscopyStereochemistryMephobarbitalBiochemistrylaw.inventionIonInorganic ChemistryMetalStructure-Activity RelationshiplawSeizuresAnimalsChelationIsostructuralElectron paramagnetic resonanceHyperfine structureChelating AgentsElectroshockMolecular StructureChemistryElectron Spin Resonance SpectroscopyChromophoreCrystallographyCovalent bondMetalsvisual_artPhenobarbitalvisual_art.visual_art_mediumAnticonvulsantsCopper

description

Abstract Na2Ni(phenobarbiturato)4·3H2O, Na2Ni3(phenobarbiturato)2(OH)6·4H2O, and NaZn(phenobarbiturato)2(OH)·H2O derivatives were prepared from Ni(II) and Zn(II) and phenobarbital. The Na2Ni(phenobarbiturato)4·3H2O complex is diamagnetic and isostructural with the complex previously reported, Na2Cu(phenobarbiturato)4, suggesting a square-planar environment around the Ni(II) ion. The DMF solutions of this complex show the existence of two species. The EPR spectra of the Cu(II) doped complex show the hyperfine and superhyperfine structures. The covalence parameters α2, β2, and δ2 show a strong bonding in the equatorial plane and suggests the formation of a [CuN4] chromophore. The anticonvulsant properties of the K2Gu(N-methylphenobarbiturato)4·8H2O are reported.

yearjournalcountryeditionlanguage
1992-03-01Journal of inorganic biochemistry
10.1016/0162-0134(92)84011-bhttps://pubmed.ncbi.nlm.nih.gov/1320103