6533b824fe1ef96bd1281665
RESEARCH PRODUCT
Mechanisms of RNA loading into exosomes
Maja M. JanasKarolina SapońTadeusz JanasTadeusz JanasTeresa Janassubject
CeramideBiophysicsBiologyExosomesModels BiologicalBiochemistryIntraluminal vesiclesCeramideMembrane Lipidschemistry.chemical_compoundRaftsMembrane MicrodomainsStructural BiologymicroRNAGeneticsExtracellularAnimalsHumansMolecular BiologyVesicleCell MembraneMembraneMultivesicular BodiesRNA-Binding ProteinsRNAMicroRNACell BiologyRaftMicrovesiclesCell biologychemistryCytoplasmRNAlipids (amino acids peptides and proteins)description
AbstractUpon fusion of multivesicular bodies (MVBs) with the plasma membrane, intraluminal vesicles (ILVs) are released into the extracellular space as exosomes. Since the lipid composition of the exosomal membrane resembles that of raft microdomains, the inward budding process involves the raft-like region of the MVB limiting membrane. Although published research suggests that cellular RNAs may be selectively sorted into exosomes, the molecular mechanisms remain elusive. In this review, we suggest that there is a continuous interaction of cellular RNAs with the outer (cytoplasmic) surface of MVBs and that the selection for incorporation of these RNAs into ILVs is based on their affinity to the raft-like region in the outer layer of the MVB membrane.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-04-03 | FEBS Letters |