An Unexpected Three-Component Condensation Leading to Amino(3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)acetonitriles.

6533b825fe1ef96bd1281c31

RESEARCH PRODUCT

An Unexpected Three-Component Condensation Leading to Amino(3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)acetonitriles.

subject

chemistry.chemical_compound Primary (chemistry)Acetonitriles chemistry Stereochemistry Cyanide Condensation Hydrogen cyanide Molecule Amine gas treating General Medicine Medicinal chemistry

description

The reaction of 2-carboxybenzaldehyde with primary amines in the presence of cyanide leads to the formation of 2-substituted amino(3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)acetonitriles. These compounds originate from the condensation of 2-carboxybenzaldehyde with the amine and two molecules of hydrogen cyanide and represent a novel class of isoindolinones.

year	journal	country	edition	language
2005-04-26	ChemInform

https://doi.org/10.1002/chin.200517119

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