6533b825fe1ef96bd1281e6f

RESEARCH PRODUCT

Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe

M. MoutschenLaura Marije Arije HofstraNicolas SauvageotJan AlbertIvailo AlexievFederico GarciaDaniel StruckDe Vijver VanBirgitta ÅSjöDanail BeshkovSuzie CoughlanDiane DescampsAlgirdas GriskeviciusOsamah HamoudaAndrzej HorbanMarjo Van KasterenTatjana KolupajevaLeontios G. KostrikisKirsi LiitsolaMarek LinkaOrna MorClaus NielsenDan OteleaDimitrios N. ParaskevisRoger ParedesMario PoljakElisabeth Puchhammer-stöcklAnders SönnerborgDanica StanekováMaja StanojevicKristel Van LaethemMaurizio ZazziSnjezana Zidovec LepejCharles A. B. BoucherJean-claude SchmitAnnemarie M. J. WensingE. Puchhammer-stocklM. SarclettiB. SchmiedM. GeitG. BalluchA. M. VandammeJ. VercauterenI. DerdelinckxA. SasseM. BogaertH. CeunenA. De RooS. De WitF. EchahidiK. FransenJ. -C GoffardP. GoubauE. GoudeseuneJ. -C YombiP. LacorC. LiesnardD. PierardR. RensY. SchrootenD. VairaL. P. R. VandekerckhoveDen Heuvel VanDer Gucht VanM. Van RanstE. Van WijngaerdenB. VandercamM. VekemansC. VerhofstedeN. ClumeckK. Van LaethemDanail BeshkovIvailo AlexievS. Z. LepejJ. BegovacLeontios G. KostrikisIoannis DemetriadesIoanna KousiappaVictoria L. DemetriouJohana HezkaM. LinkaM. MalyL. MachalaC. NielsenL. B. JørgensenJ. GerstoftL. MathiesenC. PedersenH. NielsenA. LaursenB. KvinesdalK. LiitsolaM. RistolaJ. SuniJ. SutinenD. DescampsL. AssoumouG. CastorM. GrudeP. FlandreA. StortoO. HamoudaC. KüchererT. BergP. BraunG. PoggenseeM. DäumerJ. EberleH. HeikenR. KaiserH. KnechtenK. KornH. MüllerS. NeiferB. SchmidtH. WalterB. Gunsenheimer-bartmeyerT. HarrerDimitrios N. ParaskevisAngelos E. HatzakisAssimina ZavitsanouA. VassilakisMarios C. LazanasMaria C. ChiniA. LioniV. SakkaSofia KourkountiVassilios A. PaparizosAnastasia C. AntoniadouAntonios I. PapadopoulosGaryphallia G. PoulakouI. KatsarolisK. ProtopapasGeorgios ChryssosStylianos DrimisPanagiotis GargalianosGeorgios XylomenosG. LouridaMina A. PsichogiouGeorge L. DaikosN. V. SipsasAthanasios N. KontosM. N. GamaletsouGeorgios KoratzanisH. SambatakouH. MariolisA. SkoutelisV. PapastamopoulosO. GeorgiouPeriklis PanagopoulosE. MaltezosS. CoughlanC. De GascunC. ByrneM. DuffyC. BerginD. ReidyG. FarrellJ. LambertE. O'connorA. RochfordJ. LowP. CoakelyS. O'deaW. HallO. MorI. LeviD. ChemtobZ. GrossmanM. ZazziA. De LucaClaudia BalottaC. RivaC. MussiniI. CarammaA. CapettiM. C. ColomboC. RossiF. PratiF. TramutoF. VitaleM. CiccozziG. AngaranoG. RezzaT. KolupajevaO. VasinsA. GriskeviciusV. LipnickieneJ. C. SchmitD. StruckNicolas SauvageotR. HemmerV. ArendtC. MichauxT. StaubC. Sequin-devauxA. M. J. WensingC. A. B. BoucherDe Vijver VanA. Van KesselP. H. M. Van BentumK. BrinkmanB. J. ConnellDer Ende VanI. M. HoepelmanM. Van KasterenM. KuipersN. LangebeekC. RichterR. M. W. J. SantegoetsL. Schrijnders-guddeR. SchuurmanDe Ven VanBirgitta ÅSjöA. -M B. KranV. OrmaasenP. AavitslandA. HorbanJ. J. StanczakG. P. StanczakE. Firlag-burkackaA. Wiercinska-drapaloE. JablonowskaE. MaolepszaM. Leszczyszyn-pynkaW. SzataRicardo J. CamachoC. PalmaF. BorgesT. PaixãoV. DuqueF. AraújoD. OteleaS. ParaschivA. M. TudorR. CernatC. ChiriacF. DumitrescuL. J. PrisecariuM. StanojevicDj JevtovicD. SalemovicD. StanekovaM. HabekovaZ. ChabadováT. DrobkovaP. BukovinovaA. ShunnarP. TruskaM. PoljakM. LunarDunja Z. BabicJ. TomazicL. VidmarT. VovkoP. KarnerF. GarciaR. ParedesS. MongeS. MorenoJ. Del AmoV. AsensiJ. L. SirventC. De MendozaR. DelgadoF. GutiérrezJ. BerenguerS. Garcia-bujalanceNatalia C. StellaLos Santos DeJ. R. BlancoD. DalmauM. RiveroF. SeguraMarıá Jesús Pérez ElıásM. AlvarezN. ChuecaC. Rodríguez-martínC. VidalJ. C. PalomaresI. VicianaP. VicianaJ. CordobaA. AguileraP. DomingoM. J. GalindoC. MirallesM. A. Del PozoE. RiberaJ. A. IribarrenL. RuizLa Torre DeF. VidalB. ClotetJan AlbertA. HeidarianK. Aperia-peipkeM. AxelssonM. MildA. KarlssonA. SönnerborgA. ThalmeL. NavérG. BrattA. KarlssonA. BlaxhultM. GisslénB. SvennerholmI. BergbrantPer BjörkmanC. SällÅ. MellgrenA. LindholmN. KuylenstiernaR. MonteliusF. AzimiB. JohanssonM. CarlssonE. JohanssonB. LjungbergH. EkvallA. StrandS. MäkitaloS. ÖBergP. HolmbladM. HöferH. HolmbergP. JosefsonU. RydingM. MoutschenLaura Marije Arije HofstraNicolas SauvageotJan AlbertIvailo AlexievFederico GarciaDaniel StruckDe Vijver VanBirgitta ÅSjöDanail BeshkovSuzie CoughlanDiane DescampsAlgirdas GriskeviciusOsamah HamoudaAndrzej HorbanMarjo Van KasterenTatjana KolupajevaLeontios G. KostrikisKirsi LiitsolaMarek LinkaOrna MorClaus NielsenDan OteleaDimitrios N. ParaskevisRoger ParedesMario PoljakElisabeth Puchhammer-stöcklAnders SönnerborgDanica StanekováMaja StanojevicKristel Van LaethemMaurizio ZazziSnjezana Zidovec LepejCharles A. B. BoucherJean-claude SchmitAnnemarie M. J. WensingE. Puchhammer-stocklM. SarclettiB. SchmiedM. GeitG. BalluchA. M. VandammeJ. VercauterenI. DerdelinckxA. SasseM. BogaertH. CeunenA. De RooS. De WitF. EchahidiK. FransenJ. -C GoffardP. GoubauE. GoudeseuneJ. -C YombiP. LacorC. LiesnardD. PierardR. RensY. SchrootenD. VairaL. P. R. VandekerckhoveDen Heuvel VanDer Gucht VanM. Van RanstE. Van WijngaerdenB. VandercamM. VekemansC. VerhofstedeN. ClumeckK. Van LaethemDanail BeshkovIvailo AlexievS. Z. LepejJ. BegovacLeontios G. KostrikisIoannis DemetriadesIoanna KousiappaVictoria L. DemetriouJohana HezkaM. LinkaM. MalyL. MachalaC. NielsenL. B. JørgensenJ. GerstoftL. MathiesenC. PedersenH. NielsenA. LaursenB. KvinesdalK. LiitsolaM. RistolaJ. SuniJ. SutinenD. DescampsL. AssoumouG. CastorM. GrudeP. FlandreA. StortoO. HamoudaC. KüchererT. BergP. BraunG. PoggenseeM. DäumerJ. EberleH. HeikenR. KaiserH. KnechtenK. KornH. MüllerS. NeiferB. SchmidtH. WalterB. Gunsenheimer-bartmeyerT. HarrerDimitrios N. ParaskevisAngelos E. HatzakisAssimina ZavitsanouA. VassilakisMarios C. LazanasMaria C. ChiniA. LioniV. SakkaSofia KourkountiVassilios A. PaparizosAnastasia C. AntoniadouAntonios I. PapadopoulosGaryphallia G. PoulakouI. KatsarolisK. ProtopapasGeorgios ChryssosStylianos DrimisPanagiotis GargalianosGeorgios XylomenosG. LouridaMina A. PsichogiouGeorge L. DaikosN. V. SipsasAthanasios N. KontosM. N. GamaletsouGeorgios KoratzanisH. SambatakouH. MariolisA. SkoutelisV. PapastamopoulosO. GeorgiouPeriklis PanagopoulosE. MaltezosS. CoughlanC. De GascunC. ByrneM. DuffyC. BerginD. ReidyG. FarrellJ. LambertE. O'connorA. RochfordJ. LowP. CoakelyS. O'deaW. HallO. MorI. LeviD. ChemtobZ. GrossmanM. ZazziA. De LucaClaudia BalottaC. RivaC. MussiniI. CarammaA. CapettiM. C. ColomboC. RossiF. PratiF. TramutoF. VitaleM. CiccozziG. AngaranoG. RezzaT. KolupajevaO. VasinsA. GriskeviciusV. LipnickieneJ. C. SchmitD. StruckNicolas SauvageotR. HemmerV. ArendtC. MichauxT. StaubC. Sequin-devauxA. M. J. WensingC. A. B. BoucherDe Vijver VanA. Van KesselP. H. M. Van BentumK. BrinkmanB. J. ConnellDer Ende VanI. M. HoepelmanM. Van KasterenM. KuipersN. LangebeekC. RichterR. M. W. J. SantegoetsL. Schrijnders-guddeR. SchuurmanDe Ven VanBirgitta ÅSjöA. -M B. KranV. OrmaasenP. AavitslandA. HorbanJ. J. StanczakG. P. StanczakE. Firlag-burkackaA. Wiercinska-drapaloE. JablonowskaE. MaolepszaM. Leszczyszyn-pynkaW. SzataRicardo J. CamachoC. PalmaF. BorgesT. PaixãoV. DuqueF. AraújoD. OteleaS. ParaschivA. M. TudorR. CernatC. ChiriacF. DumitrescuL. J. PrisecariuM. StanojevicDj JevtovicD. SalemovicD. StanekovaM. HabekovaZ. ChabadováT. DrobkovaP. BukovinovaA. ShunnarP. TruskaM. PoljakM. LunarDunja Z. BabicJ. TomazicL. VidmarT. VovkoP. KarnerF. GarciaR. ParedesS. MongeS. MorenoJ. Del AmoV. AsensiJ. L. SirventC. De MendozaR. DelgadoF. GutiérrezJ. BerenguerS. Garcia-bujalanceNatalia C. StellaLos Santos DeJ. R. BlancoD. DalmauM. RiveroF. SeguraMarıá Jesús Pérez ElıásM. AlvarezN. ChuecaC. Rodríguez-martínC. VidalJ. C. PalomaresI. VicianaP. VicianaJ. CordobaA. AguileraP. DomingoM. J. GalindoC. MirallesM. A. Del PozoE. RiberaJ. A. IribarrenL. RuizLa Torre DeF. VidalB. ClotetJan AlbertA. HeidarianK. Aperia-peipkeM. AxelssonM. MildA. KarlssonA. SönnerborgA. ThalmeL. NavérG. BrattA. KarlssonA. BlaxhultM. GisslénB. SvennerholmI. BergbrantPer BjörkmanC. SällÅ. MellgrenA. LindholmN. KuylenstiernaR. MonteliusF. AzimiB. JohanssonM. CarlssonE. JohanssonB. LjungbergH. EkvallA. StrandS. MäkitaloS. ÖBergP. HolmbladM. HöferH. HolmbergP. JosefsonU. Ryding

subject

MaleHuman immunodeficiency virus 1EtravirineRNA directed DNA polymerase inhibitordarunavirHIV InfectionsSettore MED/42 - Igiene Generale E Applicata:Disciplines and Occupations::Health Occupations::Medicine::Public Health [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Salud públicageneticsInhibidores de proteasas:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings]atazanavirmedia_commontransmission:Geographicals::Geographic Locations::Europe [Medical Subject Headings]3. Good healthmicrobial sensitivity testpriority journalEurope ; HIV-1 ; antiretroviral therapy ; drug resistance ; transmissionHIV/AIDSlamivudineReverse Transcriptase Inhibitors/pharmacologyanti human immunodeficiency virus agentDrugMicrobiology (medical)medicine.medical_specialtyantiviral susceptibility:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings]media_common.quotation_subjectantiretroviral therapy030106 microbiologyHIV Infections/drug therapy:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents::Anti-Retroviral Agents::Reverse Transcriptase Inhibitors [Medical Subject Headings]Microbial Sensitivity TestsRILPIVIRINEArticleEFAVIRENZ03 medical and health sciencestransmitted drug resistanceSDG 3 - Good Health and Well-beingHumansTransmissionhuman:Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance [Medical Subject Headings]REVERSE-TRANSCRIPTASE INHIBITORSRilpivirinaINTEGRASEMUTATIONSabacavirmajor clinical studyVirologyInfecciones por VIHRegimenAntiretroviral therapy; Drug resistance; Europe; HIV-1; Transmission; Medicine (all); Microbiology (medical); Infectious DiseaseschemistryDrug resistance:Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Oxazines::Benzoxazines [Medical Subject Headings]MutationHIV-10301 basic medicinenevirapineDrug resistanceCommunicable diseases:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals [Medical Subject Headings]chemistry.chemical_compoundantiviral therapyINFECTIONMedicine and Health SciencesPrevalence:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [Medical Subject Headings]ViralNon-U.S. Gov'tReverse-transcriptase inhibitorantiretrovirus agentResearch Support Non-U.S. Gov'tMedicine (all)Human immunodeficiency virus infected patientMiddle AgedvirologyPREVALENCEAntiretroviral therapyEncuestas y CuestionariosANTIRETROVIRAL TREATMENTEuropeInfectious DiseasesHIV-1/drug effectsHIV Protease Inhibitors/pharmacologyRilpivirineReverse Transcriptase Inhibitors:Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections [Medical Subject Headings]FemaleHIV drug resistancemedicine.drugAdultHuman immunodeficiency virus proteinase inhibitor:Chemicals and Drugs::Organic Chemicals::Nitriles::Rilpivirine [Medical Subject Headings]EfavirenzAnti-HIV AgentsResearch SupportResistencia a medicamentosSettore MED/17 - MALATTIE INFETTIVEantiviral resistanceInternal medicineAnti-HIV Agents/pharmacologyDrug Resistance ViralJournal Articlemedicine:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors [Medical Subject Headings]abacavir plus lamivudineEuropa (Continente)Antiretroviral therapy; Drug resistance; Europe; HIV-1; Transmission; Adult; Anti-HIV Agents; Drug Resistance Viral; Europe; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Prevalence; Reverse Transcriptase Inhibitors; Microbiology (medical); Infectious DiseasesemtricitabinenonhumanIntervalos de confianzadrug resistanceMutaciónAntiretroviral therapy; Drug resistance; Europe; HIV-1; Transmissionbusiness.industryHIVpredictionInhibidores de la transcriptasa inversaHIV Protease InhibitorsHuman immunodeficiency virus 1 infectiontenofovirINDIVIDUALSDrug Resistance Viral/geneticsBenzoxazinasETRAVIRINEdrug effects3121 General medicine internal medicine and other clinical medicinePrevalenciabusiness

description

Transmitted human immunodeficiency virus drug resistance in Europe is stable at around 8%. The impact of baseline mutation patterns on susceptibility to antiretroviral drugs should be addressed using clinical guidelines. The impact on baseline susceptibility is largest for nonnucleoside reverse transcriptase inhibitors.

yearjournalcountryeditionlanguage
2016-03-01
10.1093/cid/civ963http://hdl.handle.net/11365/995728