0000000000472050
AUTHOR
R. Kaiser
Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe
Background: One out of ten newly diagnosed patients in Europe was infected with a virus carrying a drug resistant mutation. We analysed the patterns over time for transmitted drug resistance mutations (TDRM) using data from the European Spread program.Methods: Clinical, epidemiological and virological data from 4317 patients newly diagnosed with HIV-1 infection between 2002 and 2007 were analysed. Patients were enrolled using a pre-defined sampling strategy.Results: The overall prevalence of TDRM in this period was 8.9% (95% CI: 8.1-9.8). Interestingly, significant changes over time in TDRM caused by the different drug classes were found. Whereas nucleoside resistance mutations remained con…
Fragmentation of accelerated 2.1 GeV/nucleon12C,14N and16O Ions in nuclear emulsion
The inelastic-interaction mean free path and fragmentation parameters in nuclear emulsion of accelerated 2.1 GeV/nucleon12C,14N and16O have been determined. The discrimination of the targets has been achieved with a new method. The global results obtained for the three ions have been compared with theM-group of the cosmic radiation.
The Green function and SU(3) breaking in Kl3 decays
18 páginas, 1 figura, 1 tabla.-- arXiv:hep-ph/0503108v3
Measurement of the proton and deuteron structure functions, F2p and F2d, and of the ratio
The muon-proton and muon-deuteron inclusive deep inelastic scattering cross sections were measured in the kinematic range 0.002 < x < 0.60 and 0.5 < Q(2) < 75 GeV2 at incident muon energies of 90, 120, 200 and 280 GeV. These results are based on the full data set collected by the New Muon Collaboration, including the data taken with a small angle trigger. The extracted values of the structure functions F-2(p) and F-2(d) are in good agreement with those from other experiments. The data cover a sufficient range of y to allow the determination of the ratio of the longitudinally to transversely polarised virtual photon absorption cross sections, R = sigma(L)/sigma(T), for 0.002 < x < 0.12. The …
Quark and gluon distributions and $\alpha_{s}$ from nucleon structure functions at low $x$
Abstract The Q2 dependence of the structure functions F2p and F2d recently measured by the NMC is compared with the predictions of perturbative QCD at next-to-leading order. Good agreement is observed, leading to accurate determinations of the quark and gluon distributions in the range 0.008 ⩽ × ⩽ 0.5. The strong coupling constant is measured from the low x data; the result agrees with previous determinations.
Measurement of azimuthal asymmetries associated with deeply virtual Compton scattering on a longitudinally polarized deuterium target
Azimuthal asymmetries in exclusive electroproduction of a real photon from a longitudinally polarized deuterium target are measured with respect to target polarization alone and with respect to target polarization combined with beam helicity and/or beam charge. The asymmetries appear in the distribution of the real photons in the azimuthal angle $\phi$ around the virtual photon direction, relative to the lepton scattering plane. The asymmetries arise from the deeply virtual Compton scattering process and its interference with the Bethe-Heitler process. The results for the beam-charge and beam-helicity asymmetries from a tensor polarized deuterium target with vanishing vector polarization ar…
Measurements of $R^{d}-R^{p}$ and $R^{Ca}-R^{C}$ in deep inelastic muon scattering
Results are presented on the difference in R, the ratio of longitudinally to transversely polarised virtual photon absorption cross sections, for the deuteron and the proton. They are obtained by c ...
Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe
Transmitted human immunodeficiency virus drug resistance in Europe is stable at around 8%. The impact of baseline mutation patterns on susceptibility to antiretroviral drugs should be addressed using clinical guidelines. The impact on baseline susceptibility is largest for nonnucleoside reverse transcriptase inhibitors.
Measurement of the Charge-Averaged Elastic Lepton-Proton Scattering Cross Section by the OLYMPUS Experiment
Physical review letters 126(16), 162501 (1-6) (2021). doi:10.1103/PhysRevLett.126.162501
Exclusive ϱ0 and φ muoproduction at large Q2
Abstract Exclusive ϱ 0 and φ muoproduction on deuterium, carbon and calcium has been studied in the kinematic range 2 Q 2 2 and 40 Q 2 dependence of the cross sections, the transverse momentum distributions for the vector mesons, the decay angular distributions and, in the case of the ϱ 0 , nuclear effects. The data for 0 production are compatible with a diffractive mechanism. The distinct features of φ production are a smaller cross section and less steep p t 2 distributions than those for the 0 mesons.
The A dependence of the nuclear structure function ratios
Results are presented for six nuclei from Be to Pb on the structure function ratios F-2(A)/F-2(C)(X) and their A dependence in deep inelastic muon scattering at 200 GeV incident: muon energy. The data cover the kinematic range 0.01 < x < 0.8 with Q(2) ranging from 2 to 70 GeV2. The A dependence of nuclear structure function ratios is parametrised and compared to various models.
Precision measurement of the structure function ratiosF 2 He /F 2 D ,F 2 C /F 2 D andF 2 Ca /F 2 D
We present the structure function ratiosF2He/F2D,F2C/F2D andF2Ca/F2D measured in deep inelastic muon-nucleus scattering at an incident muon momentum of 200 GeV. The kinematic range 0.0035<x<0.65 and 0.5<Q2<90 GeV2 is covered. At lowx the three ratios are significantly smaller than unity and the size of the depletion grows with decreasingx and increasing mass numberA. At intermediatex the ratios show an enhancement of about 2% above unity for C/D and Ca/D, possibly less for He/D. There are indications of someQ2 dependence in the Ca/D data. The integrals of the structure function differencesF2A−F2D are discussed.
Precision measurement of structure function ratios for $^{6}$Li, $^{12}$C and $^{40}$Ca
The structure function ratiosF2C/F2Li,F2Ca/F2Li andF2Ca/F2C were measured in deep inelastic muonnucleus scattering at an incident muon energy of 90 GeV, covering the kinematic range 0.0085<x<0.6 and 0.8<Q2<17GeV2. The sensitivity of the nuclear structure functions to the size and mean density of the target nucleus is discussed.
Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients
Background: The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, and therefore expected to revert quickly. Compensatory mutations, often already polymorphic in wild-type viruses, do not tend to revert after transmission. While compensatory mutations increase fitness during treatment, their presence may also modulate viral fitness and virulence in absence of therapy and major resistance mutations. We previously designed a modeling technique that quantifies genotypic footprints of in vivo treatment selective pressure, including both drug …
Limited cross-border infections in patients newly diagnosed with HIV in Europe
Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe.Results: Data came from the SPREAD programme which collects samples of newly diagnosed patients that are representative for national HIV epidemics. 4260 pol sequences from 25 European countries and Israel collected in 2002-2007 were included.We identified 457 clusters including 1330 persons (31.2% of all patients). The cluster size ranged bet…
Measurement of the spin-dependent structure function g1(x) of the deuteron
We report on the first measurement of the spin-dependent structure function g1d of the deuteron in the deep inelastic scattering of polarised muons off polarised deuterons, in the kinematical range 0.006<x<0.6, 1 GeV2<Q2<30 GeV2. The first moment, Γ1d=sh{phonetic}01 g1d dx=0.023±0.020 (stat.) ± 0.015 (syst.), is smaller than the prediction of the Ellis-Jaffe sum rules. Using earlier measurements of g1p, we infer the first moment of the spin-dependent neutron structure function g1n. The difference Γ1p-Γ1n=0.20 ±0.05 (stat.) ± 0.04 (syst.) agrees with the prediction of the Bjorken sum rule, Γ1p-Γ1n=0.191 ±0.002.