6533b825fe1ef96bd1281f25
RESEARCH PRODUCT
A translational paradigm to dtudy the rffects of uncontrollable stress in humans
Katja SchülerVanessa ScholzVanessa ScholzMichèle WessaMichèle WessaLaura E. MeineGal Richter-levinsubject
MalePsychological interventionLearned helplessnessTranslational Research Biomedicallcsh:ChemistryCognition0302 clinical medicineHelplessness LearnedEscape ReactionSurveys and QuestionnairesStress (linguistics)111 000 Intention & Actionlcsh:QH301-705.5Spectroscopymedia_commonlearned helplessness05 social sciencesGeneral MedicineComputer Science ApplicationsControllabilityMemory Short-TermFemalePsychological resiliencePsychologyCognitive psychologyAdultAdolescentmedia_common.quotation_subjectEscape responseTranslational researchuncontrollable stress050105 experimental psychologyCatalysisArticleInorganic ChemistryYoung Adult03 medical and health sciencesReaction TimeHumans0501 psychology and cognitive sciencesPhysical and Theoretical ChemistryMolecular BiologyresilienceAction intention and motor controlOrganic ChemistryStressorlcsh:Biology (General)lcsh:QD1-999translational researchresilience ; control ; translational research ; learned helplessness ; uncontrollable stresscontrolStress Psychological030217 neurology & neurosurgerydescription
Theories on the aetiology of depression in humans are intimately linked to animal research on stressor controllability effects. However, explicit translations of established animal designs are lacking. In two consecutive studies, we developed a translational paradigm to study stressor controllability effects in humans. In the first study, we compared three groups of participants, one exposed to escapable stress, one yoked inescapable stress group, and a control group not exposed to stress. Although group differences indicated successful stress induction, the manipulation failed to differentiate groups according to controllability. In the second study, we employed an improved paradigm and contrasted only an escapable stress group to a yoked inescapable stress group. The final design successfully induced differential effects on self-reported perceived control, exhaustion, helplessness, and behavioural indices of adaptation to stress. The latter were examined in a new escape behaviour test which was modelled after the classic shuttle box animal paradigm. Contrary to the learned helplessness literature, exposure to uncontrollable stress led to more activity and exploration
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-08-20 |