6533b825fe1ef96bd12820d4
RESEARCH PRODUCT
Tcgfiii/p40 is produced by naive murine cd4+ t cells but is not a general t cell growth factor*
B SieboldR Van BrandwijkErwin RüdeEdgar SchmittJ Van Snicksubject
CD4-Positive T-LymphocytesT cellMolecular Sequence DataImmunologyMice Inbred StrainsBiologyMajor histocompatibility complexCell LineMiceAntigenmedicineAnimalsImmunology and AllergyCytotoxic T cellInterleukin 9Amino Acid SequenceGrowth SubstancesInterleukin 4GlycoproteinsLymphokinesInterleukin-9LymphokineT-Lymphocytes Helper-InducerT lymphocyteVirologyMolecular biologymedicine.anatomical_structurebiology.proteinInterleukin-2Interleukin-4Lymphocyte Culture Test Mixeddescription
Several antigen-specific T cell lines were found to secrete a lymphokine upon activation by antigen or lectin that was provisionally termed T cell growth factor III (TCGF III) because it induced the proliferation of a CD4+ T cell clone independently from IL2 and IL4. Amino acid sequence analysis (and the functional properties of TCGF III) revealed that TCGF III was identical with a recently identified lymphokine termed P40. TCGF III/P40 was not only produced by long-term cultured T cell lines but also upon stimulation of freshly isolated Mlsa-reactive T cells. In addition, naive CD4+ T cells secreted TCGF III/P40 upon activation by lectin or allo-major histocompatibility complex structures. However, in spite of its growth-promoting activity for a CD4+ T cell clone this lymphokine does not appear to function as a general growth factor for T cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-11-01 | European Journal of Immunology |