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RESEARCH PRODUCT
ChemInform Abstract: Synthesis of meta-Terphenyl-2,2′′-diols by Anodic C-C Cross-Coupling Reactions.
Siegfried R. WaldvogelSebastian LipsAnton WiebeRobert FrankeBernd ElslerDieter SchollmeyerKatrin Marie Dyballasubject
ElectrolysisSubstrate (chemistry)General MedicineElectrochemistryCombinatorial chemistryCoupling reactionlaw.inventionPincer movementAnodechemistry.chemical_compoundchemistrylawTerphenylMoleculedescription
The anodic C−C cross-coupling reaction is a versatile synthetic approach to symmetric and non-symmetric biphenols and arylated phenols. We herein present a metal-free electrosynthetic method that provides access to symmetric and non-symmetric meta-terphenyl-2,2′′-diols in good yields and high selectivity. Symmetric derivatives can be obtained by direct electrolysis in an undivided cell. The synthesis of non-symmetric meta-terphenyl-2,2′′-diols required two electrochemical steps. The reactions are easy to conduct and scalable. The method also features a broad substrate scope, and a large variety of functional groups are tolerated. The target molecules may serve as [OCO]3− pincer ligands.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-12-01 | ChemInform |