6533b825fe1ef96bd1282650

RESEARCH PRODUCT

ChemInform Abstract: Two Triterpene Saponins from Achyranthes bidentata.

Anne Claire Mitaine-offerBernard HanquetNicolas BirlirakisAbderrazak MaroufMarie-aleth Lacaille-dubois

subject

Cisplatinchemistry.chemical_classificationbiologyGeneral Medicinebiology.organism_classificationTerpenechemistry.chemical_compoundchemistryBiochemistryHeteronuclear moleculeTriterpeneCell culturemedicineChikusetsusaponin VOleanolic acidAchyranthes bidentatamedicine.drug

description

Bidentatoside II (1) and chikusetsusaponin V methyl ester (2) are two further triterpene saponins isolated from the roots of Achyranthes bidentata. Chemical and homo and heteronuclear two-dimensional (2D) NMR techniques have led to the structural elucidation of 1 which is a new seco-glycoside of oleanolic acid and the full 1H- and 13C-NMR assignments of 2. These compounds did not show any potentiation of the in vitro cytotoxicity of cisplatin in the HT 29 human colon cancer cell line.

yearjournalcountryeditionlanguage
2010-05-21ChemInform
https://doi.org/10.1002/chin.200219170