Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro–Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice*

6533b825fe1ef96bd12826b4

RESEARCH PRODUCT

Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro–Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice*

Christian Werner Konstantin Radyushkin Bernd Moosmann Clara Luh Serge C. Thal Anja Ditter Matthias Granold Anne Sebastiani Bruno Pöttker Ralph Timaru-kast Kristin Engelhard Eva-verena Schaible Christina Gölz Philipp G. Sebastiani Michael K. E. Schäfer

subject

musculoskeletal diseases 0301 basic medicine Brain-derived neurotrophic factor Programmed cell death biology business.industry Neurotoxicity Caspase 3 Pharmacology Critical Care and Intensive Care Medicine medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine nervous system Anesthesia medicine biology.protein Low-affinity nerve growth factor receptor Receptor business 030217 neurology & neurosurgery Homeostasis Neurotrophin

description

Objectives:The gamma-aminobutyric acid modulator propofol induces neuronal cell death in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling. In adulthood, p75 neurotrophin receptor becomes down-regulated and propofol loses its neurotoxic effect. H

year	journal	country	edition	language
2016-02-01	Critical Care Medicine

https://doi.org/10.1097/ccm.0000000000001284

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