6533b825fe1ef96bd12827ba

RESEARCH PRODUCT

Sequences of isopenicillin N synthetase genes suggest horizontal gene transfer from prokaryotes to eukaryotes

Andrés MoyaJoaquín DopazoDaniel RamonMiguel A. Peñalva

subject

Genes FungalMolecular Sequence DataPenicillium chrysogenumBiologyTransfectionAspergillus nidulansGeneral Biochemistry Genetics and Molecular Biology5S ribosomal RNASequence Homology Nucleic AcidGeneGeneral Environmental ScienceGeneticsBase SequenceGeneral Immunology and MicrobiologyGenetic transferNucleic acid sequenceGeneral MedicineTransfectionbiology.organism_classificationBiological EvolutionStreptomycesAcremoniumGenes BacterialHorizontal gene transferNucleic acidOxidoreductasesGeneral Agricultural and Biological SciencesBacteria

description

Evolutionary distances between bacterial and fungal isopenicillin N synthetase (IPNS) genes have been compared to distances between the corresponding 5S rRNA genes. The presence of sequences homologous to the IPNS gene has been examined in DNAs from representative prokaryotic organisms and Ascomycotina. The results of both analyses strongly support two different events of horizontal transfer of the IPNS gene from bacteria to filamentous fungi. This is the first example of such a type of transfer from prokaryotes to eukaryotes.

yearjournalcountryeditionlanguage
1990-09-22Proceedings of the Royal Society of London. Series B: Biological Sciences
https://doi.org/10.1098/rspb.1990.0081