6533b825fe1ef96bd12827c2
RESEARCH PRODUCT
About the role of TLR2 and TLR4 in cytokine secretion by murine macrophages in response to Candida albicans.
Daniel GozalboM L Gilsubject
Microbiology (medical)medicine.medical_treatmentImmunologyMicrobiologyMicrobiologyMiceCandida albicansmedicineImmunology and AllergyAnimalsCandida albicansbiologyEffectorMacrophagesCandidiasisGeneral Medicinebiology.organism_classificationCorpus albicansToll-Like Receptor 2Toll-Like Receptor 4TLR2Infectious DiseasesCytokineImmunologyTLR4CytokinesCytokine secretionTumor necrosis factor alphadescription
Dear Editor, In a recent issue of FEMS Immunology and Medical Microbiology , Blasi (2005) studied the biological role of Toll-like receptor (TLR)2 and TLR4 in the effector and secretory responses of murine macrophages to the fungal species Candida albicans . In their article, the authors conclude that the secretory response to C. albicans appears to be TLR4- but not TLR2-dependent. In our opinion this statement is misleading as the results reported do not support this conclusion and, therefore, we wish to comment on this issue. There is evidence indicating that TLR2 is the main receptor involved in triggering cytokine production by murine macrophages in response to C. albicans . Phospholipomannan (a unique glycolipid present in the cell surface of C. albicans ) stimulates tumor necrosis factor (TNF)-α production by macrophages upon recognition …
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-02-01 | FEMS immunology and medical microbiology |