Splenomegaly Impacts Prognosis in Essential Thrombocythemia and Polycythemia Vera: A Single Center Study

6533b825fe1ef96bd12828f1

RESEARCH PRODUCT

Splenomegaly Impacts Prognosis in Essential Thrombocythemia and Polycythemia Vera: A Single Center Study

Alessandro Perez Simona Raso Paolo Casimiro Angelo Davide Contrino Antonio Russo Vincenzo Accurso Florinda Di Piazza Marco Santoro Sergio Siragusa

subject

Pediatrics medicine.medical_specialty Single Center Article 03 medical and health sciences 0302 clinical medicine Polycythemia vera Quality of life hemic and lymphatic diseases medicine Myelofibrosis Polycythemia Vera Thrombotic risk essential thrombocythemia Essential thrombocythemia business.industry lcsh:RC633-647.5 Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease Thrombosis 030220 oncology & carcinogenesis Splenomegaly splenomegaly; polycythemia vera; essential thrombocythemia business 030215 immunology

description

Splenomegaly is one of the major clinical manifestations of primary myelofibrosis and is common also in other chronic Philadelphia-negative myeloproliferative neoplasms, causing symptoms and signs and affecting quality of life of patients diagnosed with these diseases. We aimed to study the impact that such alteration has on thrombotic risk and on the survival of patients with essential thrombocythemia and patients with Polycythemia Vera (PV). We studied the relationship between splenomegaly (and its grade), thrombosis and survival in 238 patients with et and 165 patients with PV followed at our center between January 1997 and May 2019.

year	journal	country	edition	language
2019-12-04	Hematology Reports; Volume 11; Issue 4; Pages: 8281

10.4081/hr.2019.8281 https://dx.doi.org/10.4081/hr.2019.8281

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