The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma

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RESEARCH PRODUCT

The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma

Maarit Ahtiainen Satu Tommola Tuula Salo Heini Huhtala Markus Rautiainen Sanna Toppila-salmi Timo Paavonen Ahmed Al-samadi Miia Seppälä Sanni Tervo Sanni Tervo Teijo Kuopio

subject

0301 basic medicine Programmed Cell Death 1 Receptor biomarkkerit tongue squamous cell carcinoma LYMPHOCYTES 0302 clinical medicine Immunology and Allergy EPIDEMIOLOGY Receptor DISSECTION Aged 80 and over 11832 Microbiology and virology LIGAND 1 PD-L1 Mucous membrane molekyylit General Medicine Middle Aged CANCER 3. Good health Tongue Neoplasms medicine.anatomical_structure 030220 oncology & carcinogenesis immunohistochemistry Carcinoma Squamous Cell SURVIVAL Immunohistochemistry syöpätaudit Programmed cell death protein 1 (PD-1)Microbiology (medical)Adult Adolescent Pathology and Forensic Medicine 03 medical and health sciences Young Adult Immune system Antigen Tongue POOR-PROGNOSIS medicine Biomarkers Tumor Humans NECK Aged molecular marker business.industry HUMAN-PAPILLOMAVIRUS Cancer ennusteet programmed cell death protein 1 (PD‐1)medicine.disease Immune checkpoint 030104 developmental biology Cancer research T-CELLS prognosis 3111 Biomedicine business

description

Background Programmed cell death protein 1 (PD‐1) is an immune checkpoint receptor which plays an important role in a patient´s immune responses to microbial and cancer antigens. It is expressed in tumor infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD‐1 expression and its prognostic value in tongue cancer. Methods The data of tongue squamous cell carcinoma (TSCC) patients (N=81) treated in Tampere University Hospital between 1999‐2013 was used. Control data consisted of patients with non‐malignant tongue mucous membrane lesions (N=48). The formalin‐fixed paraffin‐embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD‐1 was examined semi‐quantitatively. Results The density and intensity of PD‐1+ cells were significantly higher in TSCC than in control samples. The expression of PD‐1 correlated with better survival. Conclusions The expression of PD‐1 could be a potential prognostic marker in TSCC. Further research using larger sample size is needed. peerReviewed

year	journal	country	edition	language
2020-10-19

10.1111/apm.13084 http://hdl.handle.net/10138/335432