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RESEARCH PRODUCT
ChemInform Abstract: Studies on Bicyclo[3.3.1]nonanes for Synthesis of Cyclooctenes.
Pilar BasabeAlicia JiménezSonia G. San FelicianoJulio G. UronesDavid DíezHoward B. BroughtonNarciso M. GarridoIsidro S. MarcosMargarita Parrasubject
chemistry.chemical_classificationchemistry.chemical_compoundchemistryBicyclic moleculeStereochemistryGeneral MedicineCrystal structureBridged compoundsNmr dataCinnamaldehydedescription
This paper describes a full conformational and stereochemical study of bicylo[3.3.1]nonanes, obtained from the reaction between cinnamaldehyde and 1-morpholine 1-cyclohexene. NMR data and stereochemistry were unequivocally established and assigned by two-dimensional experiments and single-crystal X-ray analysis. The crystal structure of a minor compound, 4, is reported. Cyclooctenes, which are present in natural products with biological activities, were synthesized from the bicyclononanes via the Wharton fragmentation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-19 | ChemInform |