6533b825fe1ef96bd12831eb

RESEARCH PRODUCT

Lack of association of Aspergillus colonization with the development of bronchiolitis obliterans syndrome in lung transplant recipients: An international cohort study

Deborah LevineJay AramRichard G. BarbersMuhammad YounusNancy LawPeter Chin-hongBassem HamandiDenis HadjiliadisPaolo GrossiChien-li Holmes-liewShahid HusainC. ChaparroAmparo SoléFernanda P. SilveiraPiedad UssettiEliane M. BillaudOriol ManuelLianne G. SingerErik A M VerschuurenC. Fegbeutel

subject

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyAdolescentInternational Cooperationmedicine.medical_treatmentBronchiolitis obliterans030230 surgeryCohort StudiesYoung Adult03 medical and health sciencesPostoperative Complications0302 clinical medicineRisk FactorsInternal medicinemedicineHumansLung transplantationBOSCumulative incidenceRisk factorBronchiolitis ObliteransTransplantationbusiness.industryHazard ratioMiddle Agedcolonizationmedicine.diseasehumanitiesBOS; aspergillus; colonization; lung transplantation; risk factorsTransplantationAspergillus030228 respiratory systemCohortFemaleSurgeryCardiology and Cardiovascular MedicinebusinessLung TransplantationCohort study

description

BACKGROUND: Bronchiolitis obliterans syndrome (BOS) is a major limitation in the long-term survival of lung transplant recipients (LTRs). However, the risk factors in the development of BOS remain undetermined. We conducted an international cohort study of LTRs to assess whether Aspergillus colonization with large or small conidia is a risk factor for the development of BOS.METHODS: Consecutive LTRs from January 2005 to December 2008 were evaluated. Rates of BOS and associated risk factors were recorded at 4 years. International Society of Heart and Lung Transplantation criteria were used to define fungal and other infections. A Cox proportional-hazards-model was constructed to assess the association between Aspergillus colonization and the development of BOS controlling for confounders.RESULTS: A total of 747 LTRs were included. The cumulative incidence of BOS at 4 years after transplant was 33% (250 of 747). Additionally, 22% of LTRs experienced Aspergillus colonization after transplantation. Aspergillus colonization with either large (hazard ratio [HR] = 0.6, 95% confidence interval [CI] = 0.3-1.2, p = 0.12) or small conidia (HR = 0.9, 95% CI = 0.6-1.4, p = 0.74) was not associated with the development of BOS. Factors associated with increased risk of development of BOS were the male gender (HR = 1.4, 95% CI = 1.1-1.8, p = 0.02) and episodes of acute rejection (1-2 episodes, HR = 1.5, 95% CI = 1.1-2.1, p = 0.014; 3-4 episodes, HR = 1.6, 95% CI = 1.0-2.6, p = 0.036; >4 episodes, HR = 2.2, 95% CI = 1.1-4.3, p = 0.02), whereas tacrolimus use was associated with reduced risk of BOS (HR = 0.6, 95% CI = 0.5-0.9, p = 0.007).CONCLUSIONS: We conclude from this large multicenter cohort of lung transplant patients, that Aspergillus colonization with large or small conidia did not show an association with the development of BOS.

yearjournalcountryeditionlanguage
2019-09-01The Journal of Heart and Lung Transplantation
https://doi.org/10.1016/j.healun.2019.06.007