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RESEARCH PRODUCT

Rheological and metabolic leucocyte determinants in diabetes mellitus

Anna CataniaBaldassare CaninoAntonio SarnoG. VentimigliaG. GrifòGregorio CaimiR. Lo PrestiMaria Montana

subject

medicine.medical_specialtyPhysiologyCholesterolPhospholipidhemic and immune systemsHematologyMetabolismGranulocytemedicine.diseasePeripheral blood mononuclear cellchemistry.chemical_compoundCytosolmedicine.anatomical_structureEndocrinologychemistryPhysiology (medical)Internal medicineDiabetes mellitusmedicineMembrane fluidityCardiology and Cardiovascular Medicine

description

In diabetics of type I and 2 we examined, in resting white blood cells (WBC), the filtration parameters (Initial Relative Flow Rate - lRFR, Clogging Rate - CR) employing the St. George Filtrometer, the polymorphonuclear cells (PMN) membrane fluidity, the PMN cytosolic Ca2+ content and the PMN membrane cholesterol/phospholipid ratio (C/PL). From the obtained data, it is evident that, while the lRFR of unfractionated WBC distinguishes normals from diabetics of type 1 and 2, the fIltration parameters of the PMN and mononuclear cells (MN) do not show any significant difference. PMN membrane fluidity, PMN cytosolic Ca2+ content and PMN C/PL do not discriminate normals from diabetics of type 1 and 2. No relationship is evident between WBC fIltration and metabolic parameters (fasting blood glucose level, serum cholesterol and triglycerides); no correlation is present between PMN fIltration parameters, PMN membrane fluidity and PMN metabolic determinants (cytosolic Ca2+, CIPL).

yearjournalcountryeditionlanguage
1995-01-01Clinical Hemorheology and Microcirculation
https://doi.org/10.3233/ch-1995-15107