6533b825fe1ef96bd12832d8
RESEARCH PRODUCT
Changes in pulmonary calcitonin gene-related peptide and protein gene product 9.5 innervation in rats infected with Mycoplasma pulmonis.
Axel BuobKlaus GärtnerEberhard WeiheD. Nohrsubject
MalePathologymedicine.medical_specialtyHistologyLymphoid TissueCalcitonin Gene-Related PeptideNeuropeptideBronchiNerve Tissue ProteinsCalcitonin gene-related peptideBiologyPathology and Forensic MedicineGene productRodent DiseasesmedicineAnimalsMycoplasma InfectionsLungRespiratory Tract Infectionsintegumentary systemCell BiologyPathophysiologyRatsSpecific Pathogen-Free OrganismsLymphatic systemCalcitoninRats Inbred LewNerve DegenerationMycoplasma pulmonisImmunohistochemistryThiolester HydrolasesUbiquitin ThiolesteraseBiomarkersdescription
Changes in the expression of calcitonin gene-related peptide (CGRP) and polyneural protein gene product 9.5 (PGP) in hilar peribronchial innervation was investigated by immunohistochemistry in specific pathogen-free rats chronically infected with Mycoplasma pulmonis. Image analysis of immunostained sections revealed a reduction of approximately 62% in the amount of CGRP- and PGP-immunoreactive innervation of the peribronchial area in the infected animals. The portion of the total bronchial perimeter occupied by bronchus-associated lymphoid tissue was increased six-fold. The decrease in the CGRP-immunoreactive area could be the result either of an enhanced CGRP release or of a loss of nerve fibres. The decrease in the PGP-immunoreactive fibres indicates a degenerative loss of nerves. Increased bronchus-associated lymphoid tissue and decreased bronchial innervation by neurons releasing the immunomodulatory neuropeptide CGRP might both contribute to the pathophysiology and symptoms of mycoplasmosis in the rat.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-02-01 | Cell and tissue research |