6533b825fe1ef96bd1283360
RESEARCH PRODUCT
Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis
Eugenio MocchegianiGiuseppina Colonna RomanoCalogero CarusoDomenico NuzzoGiusi I Forte 1Catia CiprianoCrivello ADomenico LioLetizia ScolaGiacalone ARobertina GiacconiGiuseppina Candoresubject
medicine.medical_treatmentSNPSingle-nucleotide polymorphismInflammationProtein Sorting SignalsBioinformaticsPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyTransforming Growth Factor beta1atherosclerosiHistory and Philosophy of ScienceGene FrequencyPolymorphism (computer science)Transforming Growth Factor betacytokineMedicineSNPHumansCarotid StenosisPromoter Regions GeneticAllele frequencyAgedAged 80 and overPolymorphism Geneticbusiness.industryGeneral NeuroscienceHaplotypePromoterSequence Analysis DNAMiddle AgedInterleukin-10carotid stenosiCytokineImmunologyIL-10medicine.symptombusinessTGF-beta 1description
The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-beta1 and IL-10 polymorphisms in atherosclerosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-06-29 |