6533b825fe1ef96bd12833a9

RESEARCH PRODUCT

Electrochemical oxidation of tetramethoxy precursor as a key step for the synthesis of coenzyme Q10

Alessandro GaliaOnofrio ScialdoneMaria Antonietta SabatinoGiuseppe Filardo

subject

Inorganic chemistrychemistry.chemical_elementSettore ING-IND/27 - Chimica Industriale E TecnologicaAnodesAnodic oxidationCarbonElectrooxidationPlatinumSynthesis (chemical)Water contentElectrochemistryElectrosynthesislcsh:ChemistrySolventchemistry.chemical_compoundSettore ING-IND/22 - Scienza E Tecnologia Dei Materialilcsh:Industrial electrochemistrylcsh:QD1-999chemistryTransition metalElectrochemistrySelectivityPlatinumAcetonitrilelcsh:TP250-261Dichloromethane

description

The feasibility of electrosynthesis of coenzyme Q10 (1) by electrooxidation of tetramethoxy precursor (2) has been investigated at carbon, Pt and BDD anodes in a divided cell. The process strongly depends on the applied potential, anode material and water content of the solvent. At carbon anodes in CH3CN/CH2Cl2 + 0.15 M Bu4NBF4 at proper operative conditions high faradic efficiency (>60%) and excellent selectivity (95–97%) of the target product were obtained. Keywords: Electrosynthesis, Coenzyme Q10, Anodic oxidation

yearjournalcountryeditionlanguage
2007-06-01Electrochemistry Communications
https://doi.org/10.1016/j.elecom.2007.01.046