Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis‐1,8‐naphthalimide Ligands

6533b825fe1ef96bd12833b8

RESEARCH PRODUCT

Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis‐1,8‐naphthalimide Ligands

Pascal Prochnow Bernhard K. Keppler Federico Lo Nardo Julia E. Bandow Ingo Ott Alessio Terenzi Wojciech Streciwilk

subject

Silver Bearing (mechanical)010405 organic chemistry Antitumor agent chemistry.chemical_element Carbene 010402 general chemistry 01 natural sciences Combinatorial chemistry Copper Ruthenium 0104 chemical sciences Rhodium Ruthenium law.invention Inorganic Chemistry chemistry Settore CHIM/03 - Chimica Generale E Inorganica law Rhodium Gold Copper Biological evaluation

description

Organometallic N-heterocyclic carbene (NHC) complexes with intercalating bis-naphthalimide ligands were prepared and evaluated biologically. Cytotoxic effects against tumor cells or bacteria were strongly ligand dependent with minor influence of the metal (Ag, Ru, Rh, Au) centers. Complex 8b with a rhodium(I) NHC moiety was studied in more detail for its DNA interacting properties in comparison to the metal free ligand. These studies showed a good DNA binding pattern with some preference for the telomeric quadruplex structure hTelo. Complex 8b was also shown to trigger additional coordinative binding to the DNA and therefore represents an useful tool compound with a mixed intercalative/coordinative DNA binding mode.

year	journal	country	edition	language
2018-06-28	European Journal of Inorganic Chemistry

https://doi.org/10.1002/ejic.201800384

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