6533b825fe1ef96bd1283432

RESEARCH PRODUCT

Effect of simvastatin on desaturase activities in liver from lean and obese zucker rats

C. ManionguiJp BlondJean BézardB. Georges

subject

Fatty Acid DesaturasesMaleSimvastatinmedicine.medical_specialtyClinical chemistryIn Vitro TechniquesBiologyLinoleoyl-CoA DesaturaseBiochemistrychemistry.chemical_compoundDelta-5 Fatty Acid DesaturaseInternal medicinemedicineAnimalsLovastatinObesityPhospholipidschemistry.chemical_classificationAnticholesteremic AgentsFatty AcidsOrganic ChemistryMetabolic disordernutritional and metabolic diseasesFatty acidCell Biologymedicine.diseaseHydroxymethylglutaryl-CoA reductaseRatsRats ZuckerEndocrinologychemistrySimvastatinFatty Acids UnsaturatedMicrosomes LiverMicrosomeArachidonic acidLipidologymedicine.drug

description

The effect of simvastatin, a hypocholesterolemic drug, on the biosynthesis of arachidonic acid was studied in obese and lean Zucker rats. After administration of 2 mg/kg body weight/d for 13 d, delta 6 and delta 5 desaturase activities were measured in liver microsomes at two substrate concentrations. In untreated rats, the delta 6 desaturation rate was similar in the obese and lean rats when measured at saturating substrate levels, whereas delta 5 desaturation was lower in the obese animals. Treatment with simvastatin did not change delta 6 desaturation in either phenotype but increased delta 5 desaturation in obese rats to reach the unchanged rate observed in lean animals. The changes were not reflected in the fatty acid composition of liver microsomal phospholipids when expressed as micrograms fatty acid/g of liver.

yearjournalcountryeditionlanguage
1993-01-01Lipids
https://doi.org/10.1007/bf02536363