6533b825fe1ef96bd128348a
RESEARCH PRODUCT
Interactions of benzodiazepines with human serum albumin. Circular dichroism studies.
Uwe WollertWerner E.g. Müllersubject
PharmacologyBenzodiazepineCircular dichroismChromatographyBinding SitesChemistrymedicine.drug_classChemical structureCircular DichroismGeneral MedicineBenzazepinesHuman serum albuminCircular dichroism spectraPartition coefficientStructure-Activity RelationshipOptical Rotatory DispersionmedicineMoleculeHumansSpectrophotometry UltravioletChlorineCotton effectSerum Albuminmedicine.drugProtein Bindingdescription
The circular dichroism spectra of 12 benzodiazepine derivatives studied in presence of human serum albumin are presented. Nearly all substances give biphasic extrinsic Cotton effects. At the CD maxima the molar ellipticities and the anisotropy factors are calculated. The influence of the chemical structure of the benzodiazepines on the induced Cotton effect is discussed. There is a linear correlation between the anisotropy factors and the logarithms of the partition coefficients of the substances. It is suggested that the phenyl ring of the benzodiazepine molecule is one of the essential groups for the binding of these substances to human serum albumin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1973-01-01 | Naunyn-Schmiedeberg's archives of pharmacology |