6533b825fe1ef96bd128348e

RESEARCH PRODUCT

Cancer chemotherapy in the older cancer patient.

Lodovico BalducciIgnazio Carreca

subject

Nephrologymedicine.medical_specialtyAgingSettore MED/06 - Oncologia MedicaUrologymedicine.medical_treatmentCardiomyopathySystemic treatmentAntineoplastic AgentsKidneyMedical OncologyPatient Care PlanningElderlyLife ExpectancyInternal medicineNeoplasmsmedicineMucositisChemotherapyHumansIntensive care medicineGeriatric AssessmentCancerAgedAged 80 and overChemotherapybusiness.industryKidney metabolismCancermedicine.diseasePeripheral neuropathyTreatment OutcomeOncologyCompression of morbiditybusiness

description

This article reviews the principles of systemic cancer treatment in older individuals. These include: assessment of physiologic age with a comprehensive geriatric assessment (CGA), adjustment of chemotherapy doses to the patient's renal function, and prevention of myelotoxicity with hemopoietic growth factors. Other complications that become more common with age include mucositis, peripheral neuropathy and cardiomyopathy. Two chronic complications of chemotherapy become more common with age, including myelodysplasia and chronic cardiomyopathy. The goal of systemic cancer treatment in the older person should include prolongation of active life-expectancy and compression of morbidity in addition to prolongation of survival and symptom management.

yearjournalcountryeditionlanguage
2009-11-01Urologic oncology
10.1016/j.urolonc.2009.08.006https://pubmed.ncbi.nlm.nih.gov/19879474