6533b826fe1ef96bd1283d8c
RESEARCH PRODUCT
Ultrasmall Rigid Particles as Multimodal Probes for Medical Applications
Claire BernhardJean-luc CollSophie LaurentAnna MignotStéphane RouxOlivier TillementPascal PerriatVasile StuparRodolphe AntoineChantal RémyLucie SanceyFrédéric BoschettiEmmanuel L. BarbierFranck DenatSandrine DufortCatherine GhezziRobert N. MullerLuce Vander ElstFrançois LuxClaire BrunetVéronique JosserandPierre MowatCédric LouisGéraldine Le DucAlexis BroisatPhilippe Dugourdsubject
Diagnostic ImagingMaleMaterials scienceGadoliniumShell (structure)Mice Nudechemistry.chemical_elementHepatic clearanceNanotechnology02 engineering and technology010402 general chemistry[ CHIM ] Chemical Sciences01 natural sciencesCatalysisMiceAnimalsHumansNanotechnology[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Particle SizeComputingMilieux_MISCELLANEOUS010405 organic chemistryAnimal imagingGeneral MedicineGeneral Chemistry021001 nanoscience & nanotechnologyRats0104 chemical sciences3. Good healthMice Inbred C57BLCore (optical fiber)chemistry[ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]NanoparticlesFemale[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]Gadolinium oxideParticle size0210 nano-technologydescription
International audience; Ultrasmall but multifunctional: Rigid imaging particles that are smaller than 5 nm in size can be obtained in a top-down process starting from a core–shell structure (core=gadolinium oxide; shell=polysiloxane). They represent the first multifunctional silica-based particles that are sufficiently small to escape hepatic clearance and enable animal imaging by four complementary techniques.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-11-04 | Angewandte Chemie International Edition |