6533b826fe1ef96bd1283dc4
RESEARCH PRODUCT
C1q–Ha matrix regulates the local synthesis of hyaluronan in malignant pleural mesothelioma by modulating has3 expression
Romana VidergarMicaela GrandolfoAlessandro MangognaFrancesco SaltonAndrea BalduitMarco ConfalonieriBeatrice BelmonteMarco BioloFabrizio ZanconatiPaola ZacchiRoberta BullaChiara Agostinissubject
hyaluronan synthaseCancer ResearchComplement systemHyaluronic acidMalignant pleural mesotheliomahyaluronan synthasesMatrix (biology)lcsh:RC254-282Articlechemistry.chemical_compoundImmune systemHyaluronan synthaseHyaluronic acidhyaluronic acidmalignant pleural mesotheliomacancertumor microenvironmentC1q; Cancer; Complement system; HAS3; Hyaluronan synthases; Hyaluronic acid; Immune system; Malignant pleural mesothelioma; Tumor microenvironmenttumor microenvironment.Cell adhesioncomplement systemC1qCancerTumor microenvironmentMessenger RNAChemistrylcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensComplement systemimmune systemHAS3Immune systemOncologyTumor microenvironmentCancer researchIntracellulardescription
Increased hyaluronic acid (HA) production is often associated with cancer progression. In malignant pleural mesothelioma (MPM), HA is found at elevated levels in pleural effusions and sera of patients, and it has been widely debated whether MPM cells are able to produce HA by themselves or through the release of growth factors stimulating other cells. Another key component of the MPM microenvironment is C1q, which can act as a pro-tumorigenic factor favoring cell adhesion, migration and proliferation. The aim of the current study was to prove that MPM primary cells are able to synthesize HA and to inquire the stimulus given by C1q&ndash
year | journal | country | edition | language |
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2021-01-22 |