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RESEARCH PRODUCT
Are Toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromes?
Annarita GiardinaGiuliana GugginoGuido SireciFrancesco CicciaGiovani TrioloFrancesco Dielisubject
lcsh:Immunologic diseases. AllergyChemokineImmunologyInflammationAutoimmunityReview ArticleCell Communicationmedicine.disease_causeAutoantigensAutoimmunityMiceimmune system diseasesToll-like receptormedicineImmunology and AllergyAnimalsHumansLupus Erythematosus SystemicDecoy receptorsReceptorskin and connective tissue diseasesSettore MED/04 - Patologia GeneraleToll-like receptors decoy receptors systemicic erythematous lupusSystemic lupus erythematosusbiologybusiness.industryToll-Like ReceptorsGeneral Medicinemedicine.diseaseImmunity Innatedecoy receptorDisease Models AnimalTumor Necrosis Factor Decoy ReceptorsRheumatoid arthritisImmunologybiology.proteinsystemicic erythematous lupusmedicine.symptomChemokinesbusinesslcsh:RC581-607Tumor Necrosis Factor Decoy ReceptorsSignal Transductiondescription
In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-08-01 |