6533b826fe1ef96bd1284604

RESEARCH PRODUCT

Parameter estimation: an advanced simulation tool in biomedicine

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Parameter estimation as an advanced tool in biomedicine have become extremely important in the study of biological systems. With increasing physiological knowledge and more efficient computers, modelling, simulation, and estimation have grown during the past 20 years to one of the most powerful tools of biomedical system analysis. Moreover modelling, simulation and estimation is of growing importance for determination of non-measurable parameters and state variables of biomedical systems as well as for case studies research of biomedical processes, which have been developed by physicians and system engineers and have also been widely accepted by biomedical scientists. These models already developed have been applied for an extensive analysis of dynamic transient behaviour under different conditions by systems simulation. In this way the most important physiologically relevant system parameters have been very often estimated from measurements obtained from experiments. However, modelling and simulation of biomedical systems is in general the inverse of the simulation process in engineering science and systems theory. For the biomedical systems have already existed and have been optimized by evolution.