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RESEARCH PRODUCT

Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias

Brendon StubbsBrendon StubbsJustin RichardsFelipe Barreto SchuchMarco SolmiPhilip B. WardNicola VeroneseDavy VancampfortSimon RosenbaumEduardo Lusa Cadore

subject

Malemedicine.medical_specialtylcsh:RC435-571Subgroup analysisReview Articlenot knownlaw.invention03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationRandomized controlled triallawRisk Factorslcsh:PsychiatryMedicineHumans030212 general & internal medicineExerciseolder adultsAgedRandomized Controlled Trials as Topicpublication biasAged 80 and overDepressive Disorder Majorbusiness.industryAge FactorsPublication biasMiddle AgedConfidence intervalExercise Therapymeta-analysisPsychiatry and Mental healthTreatment OutcomeStrictly standardized mean differenceMeta-analysisdepressionPhysical therapyFemalebusinessAnaerobic exercise030217 neurology & neurosurgeryManagement of depression

description

OBJECTIVE: To evaluate the antidepressant effects of exercise in older adults, using randomized controlled trial (RCT) data. METHODS: We conducted a meta-analysis of exercise in older adults, addressing limitations of previous works. RCTs of exercise interventions in older people with depression (≥ 60 years) comparing exercise vs. control were eligible. A random-effects meta-analysis calculating the standardized mean difference (SMD) (95% confidence interval [95%CI]), meta-regressions, and trim, fill, and fail-safe number analyses were conducted. RESULTS: Eight RCTs were included, representing 138 participants in exercise arms and 129 controls. Exercise had a large and significant effect on depression (SMD = -0.90 [95%CI -0.29 to -1.51]), with a fail-safe number of 71 studies. Significant effects were found for 1) mixed aerobic and anaerobic interventions, 2) at moderate intensity, 3) that were group-based, 4) that utilized mixed supervised and unsupervised formats, and 5) in people without other clinical comorbidities. CONCLUSION: Adjusting for publication bias increased the beneficial effects of exercise in three subgroup analysis, suggesting that previous meta-analyses have underestimated the benefits of exercise due to publication bias. We advocate that exercise be considered as a routine component of the management of depression in older adults. ispartof: Revista Brasileira de Psiquiatria vol:38 issue:3 pages:247-254 ispartof: location:Brazil status: published

yearjournalcountryeditionlanguage
2016-07-18Brazilian Journal of Psychiatry
10.1590/1516-4446-2016-1915http://europepmc.org/articles/PMC7194268