6533b826fe1ef96bd12846ab

RESEARCH PRODUCT

Quality-of-Life Outcomes in Female Patients With Ileal Conduit or Orthotopic Neobladder Urinary Diversion: 6-Month Results of a Multicenter Prospective Study

Salvatore SiracusanoAgustina ZakaPierfrancesco BassiPaolo GonteroEttore MeariniCiro ImbimboAlchiede SimonatoFabrizio Dal MoroGianluca GiannariniClaudio ValottoFrancesco MontorsiRenzo ColomboFrancesco PorpigliaRiccardo BartolettiMarco VellaAndrea MinerviniAntonio Benito PorcaroFederico RomantiniCarlo VicentiniRenato TalaminiVincenzo FicarraCristina Lonardi

subject

HRQOLCancer ResearchfemaleOncologyHRQOL; bladder cancer; female; radical cystectomy; urinary diversionurinary diversionbladder cancerbladder cancer female radical cystectomy HRQOL urinary diversionradical cystectomyhumanities

description

Radical cystectomy (RC) often affects patients’ life as this surgery is a traumatic and invasive event for the patients, with drawbacks on their daily, social, working, and sex life. Such changes in the quality of life (QoL) of patients are commonly studied through retrospective clinical evaluations and rarely with longitudinal studies. To date, studies focusing on functional outcomes, sexual function, and health-related QoL for female patients are lacking. We evaluated 37 patients using EORTC QLQ-C30 (QLQ-30) and Short-Form 36 (SF-36) questionnaires, before and after surgery, at 3 and 6 months of follow-up. The mean values for the emotional functioning in QLQ-C30 as well as the mental health in SF-36 were significantly higher in the ONB group compared to the IC group at 3 months of follow-up. These differences were not significant at 6 months of follow-up. At 6 months of follow-up, the ONB group showed a higher mean score in the physical and role functioning than the IC group. Although there was a statistically significant age difference at baseline of the two groups, none of the results are correlated with age, as demonstrated by Spearman’s analysis. The ONB seems to represent the most advantageous solution compared to the IC in terms of QOL at the 6-month follow-up.

10.3389/fonc.2022.855546http://hdl.handle.net/11562/1062281