6533b826fe1ef96bd1284903
RESEARCH PRODUCT
Effects of cyclic fatty acid monomers on the function of cultured rat cardiac myocytes in normoxia and hypoxia
E RibotP. AthiasA GrynbergA GrandgirardJ L Sebediosubject
food.ingredient030309 nutrition & dieteticsLinolenic acid[SDV]Life Sciences [q-bio]Endocrinology Diabetes and MetabolismBiology03 medical and health scienceschemistry.chemical_compoundEndocrinologyfoodLinseed oilLactate dehydrogenaseMyocyteComputingMilieux_MISCELLANEOUS030304 developmental biologychemistry.chemical_classificationMembrane potential0303 health sciencesNutrition and DieteticsFatty acidchemistryBiochemistryCULTURE DE CELLULECell cultureToxicityBiophysicsdescription
Abstract It was shown in a previous study that rat ventricular myocytes in culture do incorporate in their phospholipids the cyclic fatty acid monomers (CFAM), produced from linolenic acid by heating linseed oil. In the present study, the functional consequences of this incorporation were investigated. As compared to control cells, CFAM containing cells displayed altered electromechanical properties evidenced by decreased maximal diastolic potential, upstroke velocity and rate and a shortened action potential duration. Moreover, oxygen depletion exerted much more adverse effects on CFAM-treated cells than in control cells, such as spontaneous rhythm abnormalities, cell shortening failure and earlier and more pronounced Lactate dehydrogenase release.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-06-01 | Nutrition Research |