6533b826fe1ef96bd128491a
RESEARCH PRODUCT
Inhibition of GABA and benzodiazepine receptor binding by penicillins.
Walter E. MüllerUwe WollertAdam Antoniadissubject
Receptors Cell SurfaceFlunitrazepamPenicillinsPharmacologygamma-Aminobutyric acidBenzodiazepinesStructure-Activity RelationshipGABA receptorpolycyclic compoundsmedicineStructure–activity relationshipAnimalsgamma-Aminobutyric AcidBenzodiazepine receptor bindingChemistryGeneral NeuroscienceBrainGABA receptor antagonistReceptors GABA-AAffinitiesRatsPenicillinnervous systemBiochemistryFlunitrazepammedicine.drugdescription
Penicillins are thought to be GABA receptor antagonists. In order to determine the affinities of various penicillin derivatives for the GABA receptor, their potencies as inhibitors of specific [3H]GABA binding to rat brain membranes were investigated. All investigated penicillins inhibit specific [3H]GABA binding, with IC50 values ranging from 2 to 60 mM. The results are consistent with the assumption that penicillins are weak GABA receptor antagonists.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-07-01 | Neuroscience letters |