6533b826fe1ef96bd1284a64
RESEARCH PRODUCT
Traceless chirality transfer from a norbornene β-amino acid to pyrimido[2,1-a]isoindole enantiomers
Ferenc MiklósKristóf BozóZsolt GallaMatti HaukkaFerenc Fülöpsubject
heterocyclesfarmasiakemiaaminohapotbiologiadescription
The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(−)-(1R,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(−)-1] was successfully transfered to heterocycles (+)-9a, (+)-10a, (−)-9b, (−)-10b and (−)-10c. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 |