6533b826fe1ef96bd1284d0c

RESEARCH PRODUCT

Chronic physical conditions, multimorbidity, and mild cognitive impairment in low- and middle-Income countries

Ai KoyanagiElvira LaraBrendon StubbsAndre F. CarvalhoHans OhAndrew StickleyNicola VeroneseDavy Vancampfort

subject

Malechronic physical conditionChronic physical conditions; Low- and middle-income countries; Mild cognitive impairment; Multimorbidity; Geriatrics and GerontologyGlobal HealthArticlePrevalenceHumansCognitive DysfunctionDeveloping CountriesPovertyAgedAged 80 and overLow- and middle-income countriesMild cognitive impairmentMultimorbidityMiddle Aged*low- and middle-income countries*chronic physical conditionsChronic physical conditionsCross-Sectional Studies*mild cognitive impairmentChronic DiseaseFemale*multimorbidityGeriatrics and GerontologyDisfunção Cognitiva

description

BACKGROUND/OBJECTIVES: Chronic physical conditions and multimorbidity may be modifiable risk factors for dementia. However, data from low- and middle-income countries (LMICs) are lacking. This study thus assessed the association of chronic physical conditions and multimorbidity with mild cognitive impairment (MCI) in LMICs. DESIGN: Nationally representative, cross-sectional, community-based. SETTING: Six countries which participated in the World Health Organization’s Study on Global Ageing and Adult Health. PARTICIPANTS: 32,715 adults aged ≥50 years [mean (SD) age 62.1 (15.6) years; 51.7% females]. MEASUREMENTS: The definition of MCI was based on the recommendations of the National Institute on Ageing-Alzheimer’s Association. Ten chronic conditions (angina, arthritis, asthma, cataract, chronic lung disease, diabetes, edentulism, hearing problems, hypertension, stroke) were assessed. Multivariable logistic regression analysis was conducted to assess the association between chronic physical conditions, multimorbidity (i.e., ≥2 chronic conditions), and MCI. RESULTS: The prevalence (95%CI) of multimorbidity and MCI were 49.8% (48.1%–51.5%) and 15.3% (14.4%–16.3%), respectively. After adjustment for potential confounders, edentulism (OR=1.24), arthritis (OR=1.24), chronic lung disease (OR=1.29), cataract (OR=1.33), stroke (OR=1.94), hearing problems (OR=2.27), and multimorbidity (OR=1.40) were significantly associated with higher odds for MCI. Compared to those with no chronic conditions, there was a gradual increase in the odds for MCI ranging from one condition (OR=1.21; 95%CI=1.03–1.42) to ≥4 conditions (OR=2.07; 95%CI=1.70–2.52). CONCLUSION: These results highlight the need to investigate the underlying mechanisms linking chronic conditions and MCI, and whether the prevention or treatment of chronic conditions or multimorbidity can reduce the onset of cognitive decline and subsequent dementia especially in LMICs.

yearjournalcountryeditionlanguage
2018-01-01
http://www.repositorio.ufc.br/handle/riufc/32333