6533b826fe1ef96bd1284f40

RESEARCH PRODUCT

Cell Line and Growth Site as Relevant Parameters Governing Tumor Tissue Oxygenation

Wolfgang Mueller-klieserPeter Vaupel

subject

medicine.medical_specialtyRadiobiologyCell divisionChemistryAnemiaBlood flowOxygenationmedicine.diseaseSurgeryCell culturemedicineCancer researchArterial bloodRespiration rate

description

Experimental rodent tumors commonly used in radiobiology exhibit a large inter-individual variability in the oxygenation status [1,2] and in the hypoxic cell fraction [3,4]. Paramount factors contributing to this variability may be tumor growth stage or tumor size [5], the cell line used, the growth site, the use of anaesthesia and certain tumor-host interactions (e.g. tumor-induced anemia). Concerning the basic pathogenetic mechanisms through which the above mentioned parameters can modulate tumor tissue oxygenation, variations of nutritive blood flow, inherent characteristics of the cell line (e.g. respiration rate or tumor growth rate), and finally changes in the O2 transport capacity of the arterial blood have to be considered.

yearjournalcountryeditionlanguage
1986-01-01
https://doi.org/10.1007/978-1-4684-5188-7_76