6533b826fe1ef96bd1285020

RESEARCH PRODUCT

Oncogene-Associated Growth Behavior and Oxygenation of Multicellular Spheroids from Rat Embryo Fibroblasts

Wolfgang Mueller-klieserLeoni A. KunzKarlfried Groebe

subject

OncogeneCell growthEmbryoTumor initiationBiologymedicine.diseaselaw.inventionMetastasisMalignant transformationlawmedicineCancer researchSuppressorGene

description

It is now well documented that naturally occurring and experimentally induced tumors develop by a multistep process involving different stages such as unlimited growth, metastasis, and invasiveness. There is much evidence that malignant transformation involves activation of oncogenes and/or loss of suppressor genes (= anti-oncogenes). The former fundamental class of genes, including the ras and myc families, are associated with cell proliferation and differentiation and may mediate tumor initiation, promotion and progression (for reviews see: Spandidos, 1985; Spandidos and Anderson, 1987, Weinberg, 1989).

yearjournalcountryeditionlanguage
1994-01-01
https://doi.org/10.1007/978-1-4615-2468-7_47