6533b826fe1ef96bd12851f8

RESEARCH PRODUCT

Neoadjuvant bevacizumab and anthracycline-taxane-based chemotherapy in 678 triple-negative primary breast cancers; results from the geparquinto study (GBG 44).

Iris SchraderValentina NekljudovaJens HuoberHolm EggemannJ-u BlohmerGeorg KunzBernd GerberK KittelHans TeschH EidtmannMaik HauschildC. JackischMahdi RezaiChristine SolbachR. KreienbergClaus HanuschMichael UntchS. LoiblG. Von MinckwitzPeter A. Fasching

subject

OncologyAdultmedicine.medical_specialtyBevacizumabCyclophosphamideAnthracyclinePaclitaxelmedicine.medical_treatmentTriple Negative Breast NeoplasmsAntibodies Monoclonal HumanizedYoung AdultBreast cancerInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansAnthracyclinesEverolimusCyclophosphamideAgedEpirubicinUltrasonographySirolimusChemotherapyTaxanebusiness.industryCarcinoma Ductal BreastHematologyMiddle Agedmedicine.diseaseNeoadjuvant TherapyTumor BurdenBevacizumabTreatment OutcomeOncologyDocetaxelChemotherapy AdjuvantMultivariate AnalysisFemalebusinessmedicine.drugEpirubicin

description

Abstract Background We evaluated the pathological complete response (pCR) rate after neoadjuvant epirubicin, (E) cyclophosphamide (C) and docetaxel containing chemotherapy with and without the addition of bevacizumab in patients with triple-negative breast cancer (TNBC). Patients and methods Patients with untreated cT1c-4d TNBC represented a stratified subset of the 1948 participants of the HER2-negative part of the GeparQuinto trial. Patients were randomized to receive four cycles EC (90/600 mg/m2; q3w) followed by four cycles docetaxel (100 mg/m2; q3w) each with or without bevacizumab (15 mg/kg; q3w) added to chemotherapy. Results TNBC patients were randomized to chemotherapy without (n = 340) or with bevacizumab (n = 323). pCR (ypT0 ypN0, primary end point) rates were 27.9% without and 39.3% with bevacizumab (P = 0.003). According to other pCR definitions, the addition of bevacizumab increased the pCR rate from 30.9% to 41.8% (ypT0 ypN0/+; P = 0.004), 36.2% to 46.4% (ypT0/is ypN0/+; P = 0.009) and 32.9% to 43.3% (ypT0/is ypN0; P = 0.007). Bevacizumab treatment [OR 1.73, 95% confidence interval (CI) 1.23–2.42; P = 0.002], lower tumor stage (OR 2.38, 95% CI 1.24–4.54; P = 0.009) and grade 3 tumors (OR 1.68, 95% CI 1.14–2.48; P = 0.009) were confirmed as independent predictors of higher pCR in multivariate logistic regression analysis. Conclusions The addition of bevacizumab to chemotherapy in TNBC significantly increases pCR rates.

10.1093/annonc/mdt361https://pubmed.ncbi.nlm.nih.gov/24136883