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RESEARCH PRODUCT
The Free Oxygen Radicals Test (FORT) to assess circulating oxidative stress in patients with acute myocardial infarction
Luc RochetteCarole RichardLuc LorgisYves CottinJean-claude BeerCatherine VergelyPhilippe BuffetPierre SicardGilles DentanIsabelle L’huillierMarianne Zellersubject
Malemedicine.medical_specialtyFree Radicals030204 cardiovascular system & hematologymedicine.disease_cause03 medical and health scienceschemistry.chemical_compound0302 clinical medicineHigh-density lipoprotein[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineDiabetes mellitusmedicineHumansMyocardial infarctionAged030304 developmental biology0303 health sciencesUnivariate analysisEjection fractionbiologybusiness.industryC-reactive proteinFORTmyocardial infarction. 2 Reactive oxygen speciesMiddle Agedmedicine.disease3. Good health[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemOxidative StressMyocardial infarctionEndocrinologychemistryCardiologybiology.proteinCardiology and Cardiovascular MedicinebusinessReactive oxygen speciesBody mass indexOxidative stressdescription
International audience; Background and aim: Reactive oxygen species (ROS) play an important role in the pathogenesis of many diseases including cardiovascular diseases. Several methods have been developed for the direct or indirect measurement of oxygen free radical and its by-products. The current study was designed to validate the new Free Oxygen Radicals Test (FORT) and to investigate the potential relationships between ROS and clinical or biological factors in male patients with acute myocardial infarction (AMI). Methods: We analysed FORT values in samples from 66 patients with AMI. Results: FORT values ranged from 324 to 1198 FORT units, with a median value of 581 (494-754) FORT units. In univariate analysis, FORT values were positively related only to LVEF <40% (p=0.005), levels of CRP (r=0.438, p<0.001) and peak CK (r=0.274, p=0.028). Multiple linear regression analysis showed that CRP (p=0.023), LVEF <40% (p<0.001) and the presence of diabetes (p=0.039) were independent predictors of serum FORT values. This statistical model can explain 45% of the variance in FORT values (R 2 =0.45). Conclusions: The FORT is a simple tool to assess circulating ROS in routine clinical practice. Oxidative conditions such as inflammation and diabetes are the major determinants of FORT values in patients with AMI.
year | journal | country | edition | language |
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2010-12-01 |