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RESEARCH PRODUCT

Efficacy of TachoSil patches in controlling Dacron suture-hole bleeding after abdominal aortic aneurysm open repair

Domenico MirabellaFelice PecoraroGuido Bajardi

subject

Pulmonary and Respiratory MedicineMalemedicine.medical_specialtyBlood transfusionmedicine.medical_treatmentlcsh:SurgeryBlood Loss Surgicalsuture hole-bleedingSettore MED/22 - Chirurgia VascolareHemostaticslcsh:RD78.3-87.3Aortic aneurysmBlood Vessel Prosthesis Implantationabdominal aortic aneurysmmedicineHumansProspective StudiesProspective cohort studyAgedAged 80 and overSuturesbusiness.industryThrombinFibrinogenlcsh:RD1-811General MedicineTachoSilMiddle Agedmedicine.diseaseAbdominal aortic aneurysmSurgeryCardiac surgeryopen repairDrug CombinationsTreatment Outcomelcsh:AnesthesiologyCardiothoracic surgeryAnesthesiaFemaleSurgerybusinessCardiology and Cardiovascular MedicineAbdominal surgeryAortic Aneurysm AbdominalResearch Article

description

Abstract Purpose The aim of this study is evaluate the efficacy of TachoSil® patches in controlling suture-hole bleeding after elective infrarenal abdominal aortic aneurysm (AAA) replacement with Dacron graft. Materials and methods Patients undergoing elective replacement of infrarenal AAA with Dacron grafts were prospectively randomized to TachoSil® patches (Group I) or standard compression with surgical swabs (Group II). We evaluated time to haemostasis, blood loss during the operation, blood loss after cross-clamp removal, duration of operation, drain volume, requirement for blood transfusion and surgeons rating of efficacy. Results Twenty patients were randomized (10 patients in each treatment Group). The mean time to haemostasis was 264 ± 127.1 s (range: 180-600 s) in Group I and 408 ± 159.5 s (range: 120-720 s) in Group II (p = 0.026); mean blood loss during the operation was 503.5 ± 20.7 cc (range: 474-545 cc) in Group I and 615.7 ± 60.3 cc (range: 530-720 cc) in Group II (p ® patches. Conclusion For patients undergoing aortic reconstruction with Dacron grafts, TachoSil® patches were found to be safe and effective for the control of suture-hole bleeding.

yearjournalcountryeditionlanguage
2009-08-02
10.1186/1749-8090-4-60http://hdl.handle.net/10447/43594