6533b826fe1ef96bd128534c
RESEARCH PRODUCT
Evidence for T cell receptor-HLA class II molecule interaction in the response to superantigenic bacterial toxins
Hans-willi MittrückerBernhard Fleischersubject
MHC class IIT-LymphocytesT cellBacterial ToxinsImmunologyT-cell receptorAntigen presentationHistocompatibility Antigens Class IIReceptors Antigen T-CellAntigen-Presenting Cellsfood and beveragesT lymphocyteBiologyLymphocyte ActivationMicrobiologyCell biologymedicine.anatomical_structuremedicinebiology.proteinHumansImmunology and AllergyCytotoxic T cellAntigen-presenting cellCD8description
The staphylococcal enterotoxins and related microbial T cell mitogens stimulate T cells by cross-linking variable parts of the T cell receptor (TcR) with MHC class II molecules on accessory or target cells. In this report we describe that a given combination of T cell, accessory cell (AC) and toxin can be non-stimulatory. However, the same T cell can respond to the same toxin on another AC and the same AC can present the same toxin to another T cell. This indicates that in the complex formed between TcR, toxin and class II molecule an interaction between TcR and class II molecule takes place.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-05-01 | European Journal of Immunology |