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RESEARCH PRODUCT

An Exploratory Look at Bicuspid Aortic Valve (Bav) Aortopathy: Focus on Molecular and Cellular Mechanisms

Chiara MozziniChiara MozziniMaurizio SoresiDomenico GirelliDomenico GirelliLuciano CominaciniLuciano Cominacini

subject

medicine.medical_specialtySettore MED/09 - Medicina InternaBicuspid aortic valveHeart malformationBicuspid aortic valve; atherosclerosisInflammationRegurgitation (circulation)030204 cardiovascular system & hematologymedicine.disease_cause03 medical and health sciences0302 clinical medicineBicuspid aortic valveAneurysmBicuspid Aortic Valve DiseaseInternal medicinemedicineHumans030212 general & internal medicinebusiness.industryHemodynamicsGeneral Medicinemedicine.diseaseVulnerable plaqueStenosisInfective endocarditisAortic ValveCardiologymedicine.symptomatherosclerosisbusinessCardiology and Cardiovascular MedicineBiomarkers

description

Bicuspid aortic valve (BAV) is the most common congenital heart malformation. BAV patients are at increased risk for aortic valve disease (stenosis/regurgitation), infective endocarditis, thrombi formation and, in particular, aortic dilatation, aneurysm and dissection. This review aims at exploring the possible interplay among genetics, extracellular matrix remodeling, abnormal signaling pathways, oxidative stress and inflammation in contributing to BAV-associated aortopathy (BAV-A-A). Novel circulating biomarkers have been proposed as diagnostic tools able to improve risk stratification in BAV-A-A. However, to date, the precise molecular and cellular mechanisms that lead to BAV-A-A remain unknown. Genetic, hemodynamic and cardiovascular risk factors have been implicated in the development and progression of BAV-A-A. Oxidative stress may also play a role, similarly to what observed in atherosclerosis and vulnerable plaque formation. The identification of common pathways between these 2 conditions may provide a platform for future therapeutic solutions.

yearjournalcountryeditionlanguage
2019-01-01
10.1016/j.cpcardiol.2019.04.005http://hdl.handle.net/11562/995307