6533b826fe1ef96bd1285381

RESEARCH PRODUCT

Effects of inhibitors of cGMP-dependent protein kinase in atrial heart and aortic smooth muscle from rats

Hermann NawrathDörte Bäumner

subject

medicine.medical_specialtyContraction (grammar)Muscle RelaxationAorta ThoracicIn Vitro TechniquesMuscle Smooth VascularIsometric ContractionInternal medicineCyclic GMP-Dependent Protein KinasesmedicineAnimalsHeart AtriaProtein kinase ACyclic GMPRho-associated protein kinasePharmacologybiologyHeartMyocardial ContractionAcetylcholineRatsEnzyme ActivationEndocrinologyEnzyme inhibitorSecond messenger systemcardiovascular systembiology.proteinmedicine.symptomcGMP-dependent protein kinaseAcetylcholineMuscle Contractionmedicine.drugMuscle contraction

description

Several activators of cGMP-dependent protein kinase (protein kinase G) such as 8-Br-cGMP reduced force of contraction in rat left atria. Inhibitors of protein kinase G antagonized the negative inotropic effect of 8-Br-cGMP but not of acetylcholine in atria. However, the acetylcholine-induced relaxation in aortic rings was significantly inhibited by protein kinase G inhibition. It is concluded that the reduction by 8-Br-cGMP of force of contraction in atria is related to activation of protein kinase G. In response to acetylcholine, activation of protein kinase G is probably a major step in smooth muscle relaxation but is not involved in the reduction of force of contraction in atria.

yearjournalcountryeditionlanguage
1995-02-06European Journal of Pharmacology
https://doi.org/10.1016/0014-2999(94)00752-s