6533b826fe1ef96bd128538f

RESEARCH PRODUCT

Elastomeric Electrospun Polyurethane Scaffolds: The Interrelationship Between Fabrication Conditions, Fiber Topology, and Mechanical Properties

Nicholas J. AmorosoWilliam R. WagnerAntonio D'amoreAntonio D'amoreMichael S. SacksYi Hong

subject

Materials scienceFabricationPolyurethanesNanotechnologyElastomerArticleMuscle Smooth Vascularchemistry.chemical_compoundBiomimetic MaterialsNano-AnimalsGeneral Materials ScienceFiberComposite materialSpinningCells CulturedPolyurethaneMechanical anisotropyTissue ScaffoldsElectrospinningMechanical EngineeringElectrospinningRatsFiber topologyMandrelchemistryRats Inbred LewMechanics of MaterialsStress Mechanical

description

Electrospinning has been gaining increasing popularity in the fabrication of engineered tissue scaffolds due to its ability to produce nano to micro scale fibrous sheets. Many investigators have attempted to apply various degrees of control to this process in order to produce fiber meshes with more predictable patterns. These attempts have largely been limited to controlling fiber alignment and have fallen into two categories: physical manipulation of the fibers by pulling them into alignment using a rapidly spinning mandrel[1–3] or manipulation of the electric field during fabrication.[4, 5]

10.1002/adma.201003210http://hdl.handle.net/10447/51914