An Unexpected Three-Component Condensation Leading to Amino- (3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)- acetonitriles

6533b826fe1ef96bd12853b8

RESEARCH PRODUCT

An Unexpected Three-Component Condensation Leading to Amino- (3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)- acetonitriles

subject

chemistry.chemical_compound Acetonitriles Bicyclic molecule Chemistry Cyanide Organic Chemistry Hydrogen cyanide Molecule Amine gas treating Organic synthesis Condensation reaction Medicinal chemistry

description

The reaction of 2-carboxybenzaldehyde with primary amines in the presence of cyanide leads to the formation of 2-substituted amino(3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)acetonitriles. These compounds originate from the condensation of 2-carboxybenzaldehyde with the amine and two molecules of hydrogen cyanide and represent a novel class of isoindolinones.

year	journal	country	edition	language
2004-10-26	The Journal of Organic Chemistry

https://doi.org/10.1021/jo0486802

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