6533b826fe1ef96bd12853db

RESEARCH PRODUCT

Determination of bisphenol diglycidyl ether residues in canned foods by pressurized liquid extraction and liquid chromatography–tandem mass spectrometry

Nuria LeónVicent YusàOlga PardoAgustín Pastor

subject

Chemical ionizationDiglycidyl etherChromatographyBisphenolOrganic ChemistryTemperatureAtmospheric-pressure chemical ionizationGeneral MedicineBiochemistryHigh-performance liquid chromatographyMass SpectrometryAnalytical Chemistrychemistry.chemical_compoundAtmospheric PressurechemistryLiquid chromatography–mass spectrometrySolventsEpoxy CompoundsSolid phase extractionBenzhydryl CompoundsBisphenol A diglycidyl etherChromatography High Pressure LiquidFood Analysis

description

Abstract A new confirmatory method for simultaneous determination of bisphenol diglycidyl ether residues (BADGE, BADGE·H2O, BADGE·2H2O, BADGE·H2O·HCl, BADGE·HCl, BADGE·2HCl, BFDGE and BFDGE·2HCl) from canned food has been developed. The proposed method includes extraction by pressurized liquid extraction (PLE) followed by liquid–liquid partition and purification by solid phase extraction (SPE). Several solvent systems and different operating conditions (time, temperature) have been investigated for PLE optimization. A reversed-phase high-performance liquid chromatography (RP-HPLC) coupled to atmospheric pressure chemical ionisation tandem mass spectrometry (APCI-MS–MS) method was developed for the separation, quantification and confirmation. The ion source settings were optimized using a design of experiments (DOE). The optimized method was applied to the determination of these chemicals at very low levels in different samples with a quantification limit of 5 ng/g. Recoveries ranged between 82 and 101% and standard deviations were less than 10%.

yearjournalcountryeditionlanguage
2005-07-29Journal of Chromatography A
https://doi.org/10.1016/j.chroma.2005.11.128